Toplica wine-growing region includes wine-growing fields in the whole basin of the river Toplica and its tributaries, especially rivers Veliki and Mali Jastrebac.

Toplica wine-growing region occupies the territory of the municipalities of Blace, Prokuplje, Merošina, Doljevac and Žitorađa.

Toplica wine-growing region covers an area of 90 988,65 hectares, where the largest is Prokupac wine-growing subregion.

Prokupac wine-growing subregion occupies the western part of the area in a wide Prokupac valley at the foot of the mountain Jastrebac.

Prokupac wine-growing subregion includes parts of municipalities Prebreza, Popova, Blace, Kutlevac, Grgure, Tmava, Vrbovac, Međuhana, Kaludra, Bace, Gornja Bresnica, Velika Plana, Gornja Konjuša, Dolja Bejašnica, Gornja Rečica, Donja Rečica, Dolja Toponica, Gornja Toponica, Prekadin Gubetin, Ćukovac, Reljinac, Baboti¬nac, Bajčince, Mala Plana, Potočić, Drenovac, Smrdan, Gojinovac, Džigolj, Donja Konjuša, Tulare, Kondželj, Bresničić, Viča, Petrovac, Babin Potok, Prokuplje selo, Rastovnica, Beljire, Dobrotić, Prokuplje grad and Vodice, as well as municipalities Đurevac, Trbunje, Gornji Kaševar, Barbatovac, Čungula, Donji Kaševar, Stubal, Suvaja, Alamana, Krivaja, Gornja Draguša, Suvi do, Lazarevac, Bololjin, Svarče, Gornja Jošanica, Zdravinje, Donja Bresnica, Mršalj, Prekopuce, Končić, Mađere, Šišmanovac, Merovac, Resinac, Belogoš, Pašinac, Bulatovac, Donja Trnava, Gornja Trnava, Jugovac, Gornje Kordince, Donje Kordince, Balinovac, Đurovac, Nova Božurna, Novo Selo, Pojate and Donja Stažava.

Jugbogdan wine-growing subregion covers fields from the left side of the South Morava, in the wider area around Merošine.

Jugogdan wine-growing subregion includes parts of municipalities Krajkovac, Azbresnica, Dudulajce, Sečanica, Supovac, Lalinac, Krušce, Mramor, Aleksandrovo, Stara Božurna, Đakus, Podina, Glašince, Smrdić, Žitorađa, Pejovac, Voljčince, Šarlince, Držanovac, Samarinovac, Batušinac, Mekiš, Čapljinac, Balajnac, Aleksandrovo,as well as municipalities Deveća, Dešilovo, Biljeg, Lepaja, Oblačina, Rožina, Baličevac, Merošina, Brest, Jugbogdanovac, Kostadinovac, Gornja Rasovača, Donja Rasovača, Bučić and Gradište.

Žitorađe wine-growing subregion includes wine-growing fields in eastern and south-eastern slopes of the mountains Vidojevica.

Žitorađe wine-growing subregion includes parts of municipalitiesVlahovo, Lukomir, Rečica, Žitorađa, Studenac, Jasenica, Toponica, Konjarnik, Badnjevac, Šainovac, Doljevac, Kočane, Pukovac, Dubovo, Zlata, Mačina, Bublica, Žitni Potok, Kožince, Staro Momčilovo and municipalities Debeli Lug, Grudaš, Gornje Crnatovo, Donje Crnatovo, Donji Drenovac, Gornji Drenovac, Kare and Novo Momčilovo.