Leskovac wine-growing region covers fields distributed on all sides of the city of Leskovac, in quite broad and jagged slope of the upper basin of Južna Morava river and its tributaries such as the Pusta Reka, Veternica, and Vlasina.

Leskovac wine-growing region covers the territory of the municipalities Doljevac, Gadzin Han, Leskovac, Bojnik, Lebane and Vlasotince.

Leskovac wine-growing region occupies an area of 112 535.80 hectares, where the largest wine-growing subregion is Vinara wine-growing subregion.

Babič wine-growing subregion includes wine-growing terrain on the slopes Seličevica and Babičke gore on the right side of the Južna Morava river.

Babič wine-growing subregion includes portions of  municipalities: Klisura, Čečina, Rusna, Dukat, Gornji Barbeš, Vilandrica, Grkinja, Taskovići, Gadžin Han, Marina Kutina, Gornje Vlase, Donji Barbeš, Toponica, Novo Selo, Babičko, Gornja Lokošnica, Crkovnica, Drćevac, Jašunja, Gornja Kupinovica, Jarsenovo, Stupnica, Orašac, Velika Biljanica, Jelašnica, Grajevce, Zlokućane and Grdanica, and municipalities Smrdan, Gornja Slatina i Donja Slatina.

Pustorečje wine-growing subregion is located on the slope of the left and right sides of the Pusta river.

Pustorečje wine-growing subregion includes portions of municipalities Šarlince, Međa, Donje Brijanje, Gornje Brijanje, Kosančić, Stubla, Lapotince, Zeletovo, Bojnik, Brestovac, Dragovac, Pridvorica, Đinđuša, Lapotince, and the municipalities of Obilić, Ćukovac, Granica, Plavce, Zorovac, Crkvice, Donje Konjuvce, Gornje Konjuvce, Dubrava, Vujanovo, Orane, Lozane, Turjane, Rečica, Savinac, Mijajlica, Kamenica, Mrveš, Nova Topola, Kacabać II and Slavnik.

Vinara wine-growing subregion is a vast wine-growing subregion on hilly side of the central and southwestern part of the Leskovac area.

Vinara wine-growing subregion includes parts of  municipalities:

Kutleš, Lipovica, Čekmin, Pečenjevce, Živkovo, Priboj, Zalužnje, Vinarce, Lebane, Bačevina, Svinjarica, Krivača, Miroševce, Todorovce, Bunuša, Radonjica, Strojkovce, Palikuća, Gornja Jajina, Donja Jajina, Leskovac, Rudare, Donji Bunibrod, Gornji Bunibrod, Guberevac, Donje Stopanje, Gornje Stopanje, Svirce, Turekovac, Velika Grabovnica, Ćenovac, Donje Trnjane, Gornje Trnjane, Gornje Sinkovce, Donje Sinkovce, Pertate, Velika Kopašnica, Cekavica, Valase, Togočevce, Mala Kopašnica and Oraovica, as well as municipalities Kaštavar, Podrimce, Dušanovo, Petrovac, Belanovce, Milanovo, Karađorđevac, Kukulovce, Malo Vojilovce, Bošnjace, Lugare, Ždeglovo, Konjino, Novo Selo, Sekicol, Štulac, Prekopčelica, Veliko Vojilovce, Donje Vranovce, Drvodelja, Togočevce, Kukulovce, Šišince, Mala Grabovnica, Zagužane and Zoljevo.

Vlasotince wine-growing subregion occupies a hilly terrain on the right side of the Južna Morava river and on both sides of the river Vlasina.

Vlasotinace wine-growing subregion includes parts of municipalities Gradašnica, Lipovica, Manojlovce, Donje Krajince, Gornje Krajince, Stajkovce, Konopnica, Skrapež, Šišave, Donja Lomnica, Gornja Lomnica, Crna Bara, Crnatovo, Kruševica, Boljare, Vlasotince – out of town, Vlasotince – town, Jastrebac, Dadince, Gradište, Kovačeva Bara, Sejanica, Dedina Bara, Bojšina, Grdelica, Kozare, Orašje, Ladovica, Prilepac, Guberevac, Dobrotin, Grdelica selo, Grdelica varoš, as well as a municipality Rajino Polje.